Adult stem cells and multiple sclerosis


These are the cells that wrap their myelin-filled membranes around nerve axons to form the myelin sheath. As the disease progresses, more and more layers are destroyed and only some regions of the nerve axon are repaired with new myelin. At the end they conclude that almost half of the patients receiving HSCT did not have any progression of the disease. Myelin loss in people with MS can leave nerve fibres exposed and they can become damaged. At present, the side effects from this therapy limit its use to only those patients with the most aggressive form of MS, but trials are also being considered for patients with less severe forms. Even though the initial results of the HSCT clinical trials sound promising, the risks that are involved are not easy to ignore. What is the cause of MS?
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Stem cell transplantation for treatment of MS

Several small studies have tested transplantation of autologous MSCs, which are taken directly from an individual and used to treat that individual, with promising results. The cause of MS remains unknown, but an autoimmune reaction against oligodendrocytes and myelin is generally assumed to play a major role, and early acute MS lesions almost invariably show prominent inflammation. Such a point is marked by a significant body of experimental evidence suggesting potential clinical benefit, and a much larger evidence base for suspecting safety. JAMA , — As the autoimmune process appeared so targeted and specific, and only a single cell type, the oligodendrocyte required to be replaced. Reston, PhD, MPH, a research analyst in the Evidence-Based Practice Center at the ECRI Institute in Plymouth Meeting, Pa.
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Stem Cell Transplants May Treat Aggressive MS

Towards responsible cord blood banking models. Both oligodendrocytes and myelin are lost within patches of inflammation in MS — so-called lesions or plaques, which are readily seen on MRI scans and which, broadly, correspond to individual clinical relapse. The phase 3 trial started in originally, and has been adding patients and observing results since then. Two patients died from transplant-related complications. Neurol 22 , —
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Adult stem cells and multiple sclerosis
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Adult stem cells and multiple sclerosis
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Stem Cells and Multiple Sclerosis

Adult stem cells and multiple sclerosis



Description: That damage can lead to wide-ranging troubles, including problems with vision , speech, weakness , coordination of movement, numbness, and pain. How Well Are You Managing MS? The Journal of the American Medical Association , Feb. USA , — Such a point is marked by a significant body of experimental evidence suggesting potential clinical benefit, and a much larger evidence base for suspecting safety.

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Views: 2087 Date: 22.07.2016 Favorited: 5 favorites

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